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Molecular Oncology for Companion Animals

Kazuhiko OCHIAI, DVM, PhD

(Supervise Master Students)
Position : Associate Professor
KAKEN Researcher Number : 30550488
ORCID ID : 0000-0002-5736-0598
Main Research Theme
Research on Cancer-Related Genes in Companion Animals
Research Keywords
Genes, Proteins, Cancer, Cell Biology, Molecular Biology
Lab. Location : Departmnt of Functional Animal Anatomy
3th Floor, Building D
E-mail : kochiai(@mark)nvlu.ac.jp

Publications

1. Kawakami S, Ochiai K. et al. (2020).
(First author: Graduate students)
Novel canine isocitrate dehydrogenase 1 mutation Y208C attenuates dimerization ability.
Oncol Lett., 20(6):351.
DOI: 10.3892/ol.2020.12214
*Discovered a novel mutation in the causative gene of glioma in dogs and analyzed the associated functional changes.
2. Uemura M, Ochiai K, et al.. (2020).
(First author: Graduate students)
The canine RAD51 mutation leads to the attenuation of interaction with PALB2.
Vet Comp Oncol, 18(2):247-255.
DOI: 10.1111/vco.12542
*Analyzed the molecular functional changes caused by a mutation in the canine RAD51 gene.
3. Kawakami S, Ochiai K. et al.. (2018).
(First author: Graduate students)
R132 mutations in canine isocitrate dehydrogenase 1 (IDH1) lead to functional changes.
Vet Res Commun, 42(1):49-56.
DOI: 10.1007/s11259-017-9707-8
*Analyzed the mutation and functional changes of the IDH1 gene responsible for glioma in dogs.
4. Kawakami S, Ochiai K. et al.. (2018).
(First author: Graduate students)
Functional alteration of canine isocitrate dehydrogenase 2 (IDH2) via an R174K mutation.
J Vet Med Sci, 80(1):85-91.
DOI: 10.1292/jvms.17-0362.
*Analyzed the mutation and functional changes of the IDH2 gene responsible for glioma in dogs.
5. Kato Y, Ochiai K. et al., (2017).
(First author: Graduate students)
Canine REIC/Dkk-3 interacts with SGTA and restores androgen receptor signalling in androgen-independent prostate cancer cell lines.
BMC Vet Res, 13(1):170.
DOI: 10.1186/s12917-017-1094-4.
*Analyzed the function of the SGTA gene involved in the mechanism of refractory prostate cancer in dogs.
6. Kato Y, Ochiai K. et al.. (2015).
(First author: Graduate students)
Molecular cloning of canine co-chaperone small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) and investigation of its ability to suppress androgen receptor signalling in androgen-independent prostate cancer.
Vet J, 206(2):143-8.
DOI: 10.1016/j.tvjl.2015.08.002.
*Analyzed the structure and function of the SGTA factor involved in the progression of prostate cancer in dogs.
Detailed Information (Researchmap)