Graduate School

Doctoral course in Veterinary Medicine

The doctoral course in veterinary medicine in the graduate school offers a 4-year degree program. In this course, the students engages in high level research on the morphology and function of animals, as well as the pathogenesis, therapy, prevention of disease, veterinary public health, food and environment safety, and veterinary epidemiology.

The student can specialize in one of the following four fields: Veterinary Science I course, Veterinary Science II course, Clinical Veterinary Medicine Course or the Applied Veterinary Medicine Course.

1. Veterinary Science I course

This course provides the biochemical commonality and uniqueness of a wide range of animals. The aim of the course is to clarify the components of various animals, including the molecular structure, correlations between structure and activity, and functional roles in cell construction. Furthermore, it is intended to elucidate the essence of life activities.

2. Veterinary Science II course

This course investigates animal diseases and the physical and chemical etiological factors. The aim of this course is to instruct the student how to detect disease by searching for the mechanism of action and the pathogenesis of the illness. Furthermore, it is intended to elucidate the essence of life activities.

3. Clinical Veterinary Medicine Course

This course investigates commercial, companion, laboratory, zoo, wild and aquatic animals. The aim of this course is for the student to establish a high level of diagnostic ability, medical treatment with causal agent in a group of the farm unit, mechanisms of disease epidemics, and the condition of the individual patient. Furthermore, it is intended to elucidate how to manage animal hygiene.

4. Applied Veterinary Medicine Course

The course studies mammals, birds and a wide range of animals including fish and shellfish. The aim of this course is to study illness from a biological viewpoint, an individual level, and groups of animals at the environment level. Furthermore, it is intended to investigate environmental welfare between people and animals, prevention of zoonotic infections, and the coexistence of people and animals.

Researchers

Hajime Amasaki, DVM, Ph.D.

Professor, Division of Functional Morphology, Department of Basic Veterinary Medicine, School of Veterinary Medicine

Research: Control Mechanisms of Adaptation to evolution and Developmental System for Digestive Organ and Other Organs.

E-mail: hamasaki(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“The seminiferous epithelial cycle and microanatomy of the koala (Phascolarctos cinereus) and southern hairy-nosed wombat (Lasiorhinus latifrons) testis.” Journal of Anatomy, 222(3), 380-389 (2013)

“Histological Structure and Distribution of Carbonic Anhydrase Isozymes (CA-I, II, III and VI) in Major Salivary Glands in Koalas,” Anatomia Histokogia Embryologia, 38,449-454 (2009).

“Distributional changes of BrdU, PCNA, E2F1 and PAL31 molecules in developing murine palatal rugae.” Annals of Anatomy, 185 (6), 517-523 (2003).

Toshiro Arai, DVM, Ph.D.

Professor, Division of Functional Morphology, Department of Basic Veterinary Medicine, School of Veterinary Medicine

Research: Genetic Analysis of Mechanism of Metabolic Disorders and Tumors, Comparative Biochemistry of Energy Metabolism in Animals, Nutirigenomics in Dogs and Cats

E-mail: tarai(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Age effects on plasma cholesterol and triglyceride profiles and metabolite concentrations in dogs” BMC Veterinary Research 10, 57 (2014)

“Comparison of plasma lipoprotein profiles and malondialdehyde between hyperlipidemia dogs with/without treatment” BMC Veterinary Research 10, 67 (2014)

“A comparison of metabolic parameters between obese and non-obese healthy domestic dogs in Japan” Asian Journal of Animal and Veterinary Advances, 8, 863-873 (2013)

Makoto Bonkobara, DVM, Ph.D.

Laboratory of Veterinary Clinical Pathology, Division of Therapeutic Science I

Research: Development of molecular targeted therapy for malignancies in dogs and cats

E-mail: bonkobara(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

Selective growth inhibition by suppression of F1Fo ATPase in canine malignant melanoma cell lines. J Vet Pharmacol Ther. 2016 in press. doi: 10.1111/jvp.12336

Molecular changes associated with the development of resistance to imatinib in an imatinib-sensitive canine neoplastic mast cell line carrying a KIT c.1523A>T mutation. Eur J Haematol. 2015. 95(6):524-531.

Dysregulation of tyrosine kinases and use of imatinib in small animal practice. Vet J. 2015. 205(2):180-188.

Michio Fujita, DVM, Ph.D.

Professor, Division of Therapeutic Science I, Department of Clinical Veterinary Medicine、School of Veterinary

Research: Imaging Diagnosis、Radiation Oncology、Respiratory Diseases

E-mail: mfujita(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Tracheal narrowing secondary to airway obstruction in two cats” Journal of Small Animal Practice, 45,29-31 (2004)

“Intranasal Hemangiosarcoma in a Dog” Journal of Veterinary Medical Science, 70,525-528 (2008)

“Postoperative hypofractionated radiotherapy for canine soft tissue sarcomas of limbs: a retrospective study of 14 cases, 3,13-19 (2012)

Daisuke Hasegawa, DVM, Ph.D.

Associate Professor, Division of Therapeutic Science I, Department of Veterinary Clinical Medicine, School of Veterinary Medicine

Research: Epilepsy, Brain tumors, MRI

E-mail: disk-hsgw(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“A familial spontaneous epileptic feline strain: A novel model of idiopathic/genetic epilepsy” Epilepsy Research, 92, 85-88 (2010)

“Magnetic resonance findings of the corpus callosum in canine and feline lysosomal storage diseases” PLoS One, 8, e83455 (2013)

“Diffusion-weighted imaging in kainic acid-induced complex partial status epilepticus in dogs” Brain Research, 983, 115-127 (2003)

Shin-ichi Hayama, DVM, Ph.D.

Professor, Division of Wildlife Science II, Department of Preventive Veterinary Medicine, School of Veterinary Medicine

Research: Conservation and management for wild mammals and birds in Japan

E-mail: hayama(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Concentration of radiocesium in the wild Japanese monkey (Macaca fuscata) over the first 15 months after the Fukushima daiichi nuclear disaster” PLoS One, 8(7): e68530. doi: 10.1371/ journal. pone. 0068530. (2013)

“Pregnancy rate and conception date in a wild population of Japanese monkeys” Journal of Veterinary Medical Science, 73, 809-812 (2011)

“Geographic Analysis of Feline Immunodeficiency Virus Infection in Tsushima Leopard Cats (Preonarilusus bengalensis euptilura) and Domestic Cats on Tsushima Islands by Geographic Information System” Journal of Veterinary Medical Science, 72, 1113-1118 (2010)

Tatsuya Hori, DVM, Ph.D.

Professor, Division of Therapeutic Science II, Department of Veterinary Clinical Medicine, School of Veterinary Medicine

Research: Canine and feline reproductive physiology, artificial reproductive technology

Key articles:

“Influence of different methods of collection from the canine epididymides on post-thaw caudal epididymal sperm quality” Journal of Veterinary and Medical Science, 77, 625-630 (2015)

“Effects of storage temperature and semen extender on stored canine semen” Journal of Veterinary and Medical Science, 76, 259-263 (2013)

“Ovulation day after onset of vulval bleeding in a beagle colony” Reprodction in Domestic Animals, 47 Suppl 6, 47-51(2012).

Kazunori Ike, DVM, Ph.D.

Professor, Division of Veterinary Infectious Disease, Department of Veterinary Pathobiology, School of Veterinary Medicine

Research: Veterinary Parasitology and Bacteriology, Vaccine development

E-mail: ike-k(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Gene cloning and characterization of the protein encoded by the Neospora caninum bradyzoite-specific antigen gene BAG1” Journal of Parasitology, 99, 453-458 (2013)

“Comparative study of protective abilities of NcBAG1, NcBSR4, NcMAG1, and NcSAG4 antigens against Neospora caninum infection in acute mouse model” Parasitology Research 112, 655-663 (2013)

“Induction of T Helper 1 (Th1) immune response by an extract from Pleurotus eryngii (Eringi)” Journal of Medical Food, 15, 1124-1128 (2012)

Eiichi Kawakami, DVM, Ph.D.

Professor, Laboratory of Reproduction and Theriogenology

Research: Canine Sperm Fertilization, Therapy of Spermatogenic Dysfunction and Prostatic Diseases in the Dog

E-mail:kawakami(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Effects of hyaluronic acid on Ca influx, lactate dehydrogenase activity, and cyclic AMP synthesis in canine ejaculated sperm during in vitro capacitation” Journal of Veterinary Medical Science, 68, 119-123(2006)

“Therapeutic effects of vitamin E supplementation in 4 dogs with poor semen quality and low superoxide dismutase activity in seminal plasma” Journal of Veterinary Medical Science, 77, 1711-1714(2015)

“Occurrence of prostatic adenocarcinoma in castrated dogs and prostatic superoxide dismutase activity of healothy dogs before and after castration” Asian Journal of Animal and Veterinary Advances, 9, 362-366 (2014)

Hidekazu Koyama, DVM, Ph.D.

Professor, Division of Therapeutic Science I, Department of Veterinary Clinical Medicine, School of Veterinary Medicine

Research: Veterinary Internal Medicine, Cardiology

E-mail: hkoyama(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

Dobutamine stress echocardiography for assessment of systolic function in dogs with experimentally induced mitral regurgitation. J Vet Intern Med. 28, 386-92 (2014)

Noninvasive clinical assessment of systolic torsional motions by two-dimensional speckle-tracking echocardiography in dogs with myxomatous mitral valve disease” Journal of Veterinary Internal Medicine, 27, 69-75 (2013)

Evaluation of QT interval Prolongation in dogs with heart failure” Journal of Veterinary Medical Science, 66, 1107-1111(2004)

Osamu Kurata, Ph.D.

Professor, Laboratory of Aquatic Medicine, School of Veterinary Medicine

Research: Studies of immune response and inflammation in pathogenesis of infectious diseases in fish

E-mail: kurata(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“N-terminal region is responsible for chemotaxis-inducing activity of flounder IL-8”. Fish and Shellfish Immunology, 38, 361-366 (2014).

“Activity of granulocytes and chemokines in the leukocyte-encapsulation response of Japanese flounder Paralichthys olivaceus”. Fish Pathology 45, 121-129 (2010).

“Long-term culture of Japanese flounder Paralichthys olivaceus leukocytes”. Fish Pathology 46, 11-18 (2011).

Hiroetsu Suzuki, DVM, Ph.D.

Professor, Division of Functional Morphology, Department of Basic Veterinary Medicine, School of Veterinary Medicine

Research: Genetic and pathophysiological studies on mutated rat strains originally established in our laboratory

E-mail: hiroetsu(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“The microtubule-associated protein astrin transgenesis rescues spermatogenesis and renal function in hypogonadic (hgn/hgn) rats.” Andrology 1, 301-307 (2013)

“Insertional mutation in the Golgb1 gene is associated with osteochondrodysplasia and systemic edema in the OCD rat” Bone, 49, 1027-1036 (2011)

“A Spontaneously mutation of the Wwox gene and audiogenic seizure in rats with lethal dwarfism and epilepsy” Genes, Brain and Behavior, 8, 650-660 (2009)

Kimimasa Takahashi, DVM, Ph.D, Dipl. JCVP

Professor, Division of Pathobiologic Analysis, Department of Veterinary Pathology, School of Veterinary Medicine

Research: Tumor Pathology in Animals; Intrahepatic eosinophilic pylephlebitis in Japanese Black cattle

E-mail: kimimasa(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Investigation of the roles of fascioliasis and food allergy in intrahepatic eosionphilic proliferative pylephlebitis in Japanese Black cattle” The Veterinary Journal, 196,160-166 (2013)

“Cellular sources of tenascin-C in canine mammary carcinomas” Veterinary Pathology, 52, 92-96 (2014)

“Differences in indicators of malignancy between luminal epithelial cell type and myoepithelial cell type of simple solid carcinoma in the canine mammary gland” Veterinary Pathology, 51, 1090-1095 (2014)

Naoyuki Takemura, DVM, Ph.D.

Professor, Division of Therapeutic Science I, Department of Veterinary Clinical Medicine, School of Veterinary Medicine

Research: Cardiology and nephrology in dogs and cats

E-mail: nstakemura(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Relationship between glomerular filtration rate and plasma N-terminal pro B-type natriuretic peptide concentrations in dogs with chronic kidney disease.” Veterinary Journal, 197, 445-450 (2013)

“The diagnostic significance of the plasma N-terminal pro-B-type natriuretic peptide concentration in asymptomatic cats with cardiac enlargement.” Journal of Veterinary Medical Science, 73, 971-975 (2011)

“Evaluation of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency,” Journal of Veterinary Medical Science, 71, 925-929 (2009)

Hiroyuki Tazaki, Ph.D.

Professor, Laboratory of Biomolecular Chemistry, School of Veterinary Medicine

Research: Bioorganic Chemistry, Metabolomics, Natural Product Chemistry

E-mail: tazaki(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Non-targeted analyses of animal plasma: Betaine and choline represent the nutritional and metabolic status.” Journal of Animal Physiology and Animal Nutrition. 97 (1),119-125 (2013)

“Effects of metformin on plasma levels of glucose and mannose, G6Pase and PEPCK activity, and mRNA expression in the liver and kidney of chickens.” British Poultry Science, 52, 273-277 (2011)

“Simultaneous determination of serum mannose and glucose concentrations in dog serum using high performance liquid chromatography.” Research in Veterinary Science, 84 (1), 26-29 (2008)

Fukiko Ueda, DVM, MSc, Ph.D.

Professor, Division of Veterinary Hygiene and Public Health, Department of Preventive Veterinary Medicine, School of Veterinary Medicine

Research: Environmental Health, Foodborne Disease

Key articles:

“Biofilm Formation under Different Temperature Conditions by a Single Genotype of Persistent Listeria monocytogenes Strains.” Journal of Food Protection, 77, 133?140 (2014)

“Contents of various elements in the organs of seabirds killed by an oil spill around Tsushima Island, Japan.” Journal of Veterinary Medical Science, 75(5), 583-587 (2013)

“Interaction between titanium and cadmium in various guinea pig organs.” Biological Trace Element Research. 151(2), 209-216 (2013)

Shinpei Wada, DVM, Ph.D., Dipl. JCZWM (Aquatic Medicine)

Professor, Division of Pathobiological Analysis, Department of Veterinary Pathobiology, School of Veterinary Medicine

Research: Comparative pathology and clinical medicine for aquatic animals (mainly fish).

E-mail: swada(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“A Novel Disorder of Cultured Juvenile Greater Amberjack Seriola dumerili Characterized by Renomegaly and Splenomegaly.” Fish Pathol., 49, 7-15 (2014)

“Histopathology of Gill Lesions of Ayu Plecoglossus altivelis Clinically Diagnosed with “Boke” Disease.” Fish Pathol., 46, 59-61 (2011)

“A Study of the Effects of 2-phenoxyethanol as a Sedative and-or Anesthetic on Cow-Nosed Ray (Rhinoptera javanica).” Jpn. J. Zoo Wildl. Med., 15, 31-36 (2010)

Makoto Yokosuka, DVM, Ph.D.

Professor, Division of Pathobiological Analysis, Department of Veterinary Pathobiology, School of Veterinary Medicine

Research: Anatomical analysis of the neural circuit of the olfactory and gustatory system of the brain

E-mail: mayokosuka(X)nvlu.ac.jp *Please replace (X) by @.

Key articles:

“Prior attenuation of KiSS1/GPR54 signaling in the anteroventral periventricular nucleus is a trigger for the delayed effect induced by neonatal exposure to 17alpha-ethynylestradiol in female rats.” Reprod. Toxicol., 51, 145-156 (2015)

“Histological properties of the glomerular layer in the mouse accessory olfactory bulb.” Exp. Anim. 61,13-24 (2012)

“Histological properties of the nasal cavity and olfactory bulb of the Japanese jungle crow Corvus macrorhynchos,” Chem Senses 34,581-593 (2009)