発表論文

2023.05.31

犬の乳がん幹細胞の自己複製能を標的とした阻害剤の探索～mTORシグナル阻害剤はがん幹細胞の自己複製能を抑制する～
タイトル：mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma

道下 正貴(獣医学科)　他

2023.03.29

A feline case of multiple myeloma treated with bortezomib.

Tani H, Miyamoto R, Miyazaki T, Oniki S, Tamura K, Bonkobara M.
BMC Vet Res. 2022. 18(1):384.
doi: 10.1186/s12917-022-03484-1.

2023.03.29

In vitro anticancer effects of alpelisib against PIK3CA mutated canine hemangiosarcoma cell lines.

Maeda M, Ochiai K, Michishita M, Morimatsu M, Sakai H, Kinoshita N, Sakaue M, Onozawa E, Azakami D, Yamamoto M, Ishioka K, Sadahira T, Watanabe M, Tanaka Y.
Oncol Rep. 2022 Apr;47(4):84. doi: 10.3892/or.2022.8295.

2023.03.29

Canine Mammary Tumor Cell Lines Derived from Metastatic Foci Show Increased RAD51 Expression but Diminished Radioresistance via p21 Inhibition.

Shimakawa K, Ochiai K, Hirose S, Tanabe E, Michishita M, Sakaue M, Yoshikawa Y, Morimatsu M, Tajima T, Watanabe M, Tanaka Y.
Vet Sci. 2022 Dec 17;9(12):703. doi: 10.3390/vetsci9120703.

2023.03.29

Pulmonary solid adenocarcinoma in a dog.

Michishita M, Hanari N, Oda H, Nagashima T, Machida Y, Hamamoto Y, Tamura K, Azakami D, Ochiai K, Mori A.
J Comp Pathol. 2023 Feb;201:100-104. doi: 10.1016/j.jcpa.2023.01.006.

2023.03.29

mTOR pathway as a potential therapeutic target for cancer stem cells in canine mammary carcinoma.

Michishita M, Ochiai K, Nakahira R, Azakami D, Machida Y, Nagashima T, Nakagawa T, Ishiwata T.
Front Oncol. 2023 Jan 27;13:1100602. doi: 10.3389/fonc.2023.1100602.

2023.03.29

Reverse Genetics with a Full-Length Infectious cDNA Clone of Bovine Torovirus.

Ujike M, Etoh Y, Urushiyama N, Taguchi F, Asanuma H, Enjuanes L, Kamitani W.
J Virol. 2022 96(3):e0156121.

2023.03.29

Reduction of Cell Fusion by Deletion in the Hypervariable Region of the Spike Protein of Mouse Hepatitis Virus.

Tennakoon N, Ryu J, Ujike M, Taguchi F, Shin HJ.
Viruses. 2022 14(2):398.

2023.03.29

Identification of trypsin-degrading commensals in the large intestine.

Li Y, Watanabe E, Kawashima Y, Plichta DR, Wang Z, Ujike M, Ang QY, Wu R, Furuichi M, Takeshita K, Yoshida K, Nishiyama K, Kearney SM, Suda W, Hattori M, Sasajima S, Matsunaga T, Zhang X, Watanabe K, Fujishiro J, Norman JM, Olle B, Matsuyama S, Namkoong H, Uwamino Y, Ishii M, Fukunaga K, Hasegawa N, Ohara O, Xavier RJ, Atarashi K, Honda K.
Nature. 2022 609(7927):582-589.

2023.03.29

Trends of mismatches in real-time RT-PCR assays developed by the National Institute of Infectious Diseases, Japan for Omicron variants of severe acute respiratory syndrome coronavirus 2.

Shirato K, Ujike M, Kawase M.
Jpn J Infect Dis. 2022

2023.03.29

ingle Amino Acid Substitution in the Receptor Binding Domain of Spike Protein Is Sufficient To Convert the Neutralization Profile between Ethiopian and Middle Eastern Isolates of Middle East Respiratory Coronavirus.

Sugimoto S, Kakizaki M, Kawase M, Kawachi K, Ujike M, Kamitani W, Sentsui H, Shirato K.
Microbiol Spectr. 2023 e0459022.

2023.03.29

Histological, immunohistochemical and ultrastructural features of polyglucosan bodies in uterine smooth muscle of pet rabbits (Oryctolagus cuniculus)

Hisashi Yoshimura, Kazushi Torikai, Anna Takahashi, Masaki Michishita, Takuya E Kishimoto, Masami Yamamoto, Makoto Haritani, Kimimasa Takahashi, Shinji Kamiya
Journal of Comparative Pathology 201,28-32,2023

2023.03.08

犬と猫のてんかん外科：導入完了,そしてこれから
タイトル：
1．Neurosurgery in canine epilepsy
2.Neurosurgery in feline epilepsy, including clinicopathology of feline epilepsy syndromes

長谷川 大輔（獣医学科）　他

2022.12.02

ポメラニアンのてんかんにおける特徴的な発作症状：足のひきつけを伴う焦点性運動発作
タイトル：Clinical characterization of epileptic seizures in Pomeranians with idiopathic epilepsy or epilepsy of unknown cause

長谷川 大輔(獣医学科)　他

2022.03.30

In vitro anticancer effects of alpelisib against PIK3CA mutated canine hemangiosarcoma cell lines

Maeda M, Ochiai K, Michishita M, Morimatsu M, Sakai H, Kinoshita N, Sakaue M, Onozawa E, Azakami D, Yamamoto M, Ishioka K, Sadahira T, Watanabe M, Tanaka Y.
Oncology Reports.2022, 47(4):84.

2022.03.30

Molecular characterization of canine SHP2 mutants and anti-tumour effect of SHP2 inhibitor, SHP099, in a xenograft mouse model of canine histiocytic sarcoma.

Tani H, Miyamoto R, Nagashima T, Michishita M, Tamura K, Bonkobara M. Vet Comp Oncol. 2021 Jul 9.

2022.03.30

A canine case of malignant melanoma carrying a KIT c.1725_1733del mutation treated with toceranib: a case report and in vitro analysis.

Tani H, Miyamoto R, Noguchi S, Kurita S, Nagashima T, Michishita M, Yayoshi N, Tamura K, Bonkobara M. BMC Vet Res. 2021;17(1):147.

2022.03.30

Primary pulmonary diffuse large B-cell lymphoma associated with feline leukaemia virus infection in a young cat.

Ishikawa K, Nagashima T, Machida Y, Yasuda A, Yoshida K, Fujita M, Ochiai K, Azakami D, Michishita M.
JFMS Open Rep.
2022 Feb 11;8(1):20551169221074240.

2022.03.30

Subleukaemic T-Lymphoblastic Leukaemia in a Horse.

Michishita M, Shibata R, Machida Y, Matsumoto M, Ochiai K, Azakami D.
J Comp Pathol. 2021 188:21-25.

2022.03.30

Gastric Plasmacytoma with Immunoglobulin Lambda Light Chain Deposition in a Dog.

Hanari N, Nagashima T, Machida Y, Kubo Y, Hamamoto Y, Kamiie J, Ochiai K, Azakami D, Michishita M.
J Comp Pathol. 2021 187:7-10.

2022.03.30

Morphofunctional analysis of human pancreatic cancer cell lines in 2- and 3-dimensional cultures.

Minami F, Sasaki N, Shichi Y, Gomi F, Michishita M, Ohkusu-Tsukada K, Toyoda M, Takahashi K, Ishiwata T.
Sci Rep. 2021 11(1):6775.

2022.03.30

Skeletal radiographic manifestations of GM2 gangliosidosis variant 0 (Sandhoff disease) in two Japanese domestic cats.

Yu Y, Hasegawa D, Hamamoto Y, Mizoguchi S, Fujimori T, Kubo Y, Islam Md S, Yamato O
Journal of Feline Medicine and Surgery Open Reports

2022.03.30

Ventrolateral temporal lobectomy in normal dogs as a counterpart to human anterior temporal lobectomy: a preliminary study on the surgical procedure and complications.

Asada R, Hamamoto Y, Yu Y, Mizuno S, Chambers JK, Uchida K, Hasegawa D.
Journal of Veterinary Medical Science 83:1513-1520, 2021

2022.03.30

Focal Cortical Resection and Hippocampectomy in a Cat With Drug-Resistant Structural Epilepsy.

Hasegawa D, Asada R, Hamamoto Y, Yu Y, Kuwabara T, Mizoguchi S, Chambers JK, Uchida K.
Frontiers in Veterinary Science 8:719455, 2021

2022.03.30

Case report: One-year follow-up of vagus nerve stimulation in a dog with drug-resistant epilepsy.

Hirashima J, Saito M, Igarashi H, Takagi S, Hasegawa D.
Frontiers in Veterinary Science 8:708407, 2021

2022.03.30

Immunomodulatory Effects of Canine Adipose Tissue Mesenchymal Stem Cell-Derived Extracellular Vesicles on Stimulated CD4+ T Cells Isolated from Peripheral Blood Mononuclear Cells

Takahiro Teshima, Yunosuke Yuchi, Ryohei Suzuki, Hirotaka Matsumoto, Hidekazu Koyama
Journal of Immunology Research, 2021, volume 2021

2022.02.07

牛トロウイルスの完全長感染性cDNAクローンによるリバースジェネティクス
Reverse Genetics with a Full-length Infectious cDNA Clone of Bovine Torovirus

氏家　誠（獣医学科）他

2021.12.09

犬の難治性てんかんにおける脳梁離断術の効果：明らかな発作の減少と犬と飼い主のQOLの向上が確認される
Corpus callosotomy in 3 Cavalier King Charles Spaniel dogs with drug-resistant epilepsy

長谷川大輔（獣医学科）他

2021.12.01

ネコAB式血液型における交差適合試験不適合ネコの表現型と遺伝子型の特徴
タイトル：Phenotypic and Genetic Characterization for Incompatible Cross-Match Cases in the Feline AB Blood Group System

近江　俊徳 (獣医保健看護学科)　他

2021.11.11

イヌの乳腺癌におけるNestinの発現と癌進行への関与
タイトル：Involvement of Nestin in the Progression of Canine Mammary Carcinoma

吉村　久志(獣医保健看護学科) 他

2021.11.09

症例報告：脳梁離断術を実施した原因不明の薬剤抵抗性てんかんの猫の１例
タイトル：Case Report: Corpus callosotomy in a cat with drug-resistant epilepsy of unknown cause

長谷川　大輔(獣医学科) 他

2021.03.15

猫の難治性側頭葉てんかんに対するてんかん外科 （側頭葉・海馬切除術）に世界で初めて成功！
タイトル：Focal cortical resection and hippocampectomy in a cat with drug-resistant structural epilepsy.

長谷川　大輔　(獣医学科) 他

2021.05.31

トロウイルス分子生物学研究の最前線

氏家　誠(獣医学科、生命科学総合研究センター）他
Recent Progress in Torovirus Molecular Biology

2021.03.15

CT and MRI Characteristics of Presumptive Hypervitaminosis A in a Cat.

Yu Y, Sugiyama A, Kuniya T, Hasegawa D
Journal of Feline Medicine and Surgery Open Reports, 2021 Mar 15;7(1):1-7.

2020.12.09

The Inhaled Steroid Ciclesonide Blocks SARS-CoV-2 RNA Replication by Targeting the Viral Replication-Transcription Complex in Cultured Cells.

Matsuyama S, Kawase M, Nao N, Shirato K, Ujike M, Kamitani W, Shimojima M, Fukushi S.
Journal of Virology, 2020 Dec 9;95(1):e01648-20.

2021.01.11

Comparison of Canine and Feline Meningiomas Using the Apparent Diffusion Coefficient and Fractional Anisotropy.

Wada M, Hasegawa D, Hamamoto Y, Yu Y, Asada R, Fujiwara-Igarashi A, Fujita M.
Frontiers in Veterinary Science, 2021 Jan 11;7:614026.

2020.10.31

Commitment Toward Cell Death by Activation of Autophagy with Survivin Inhibitor YM155 in Two Canine Squamous Cell Carcinoma Cell Lines with High Expression of Survivin.

Miyamoto R, Tani H, Ikeda T, Saima H, Tamura K, Bonkobara M.
Research in Veterinary Science, 2020 Oct 31:S0034-5288(20)31063-8.

2020.10.18

Generation of Insulin-Producing Cells from Canine Adipose Tissue-Derived Mesenchymal Stem Cells.

Teshima T, Okamoto K, Dairaku K, Nagashima T, Michishita M, Suzuki R, Matsumoto H, Koyama H.
Stem Cells International, 2020 Oct 18;2020:8841865.

2020.11.10

Magnetic Resonance Imaging and Histopathologic Findings from a Standard Poodle with Neonatal Encephalopathy with Seizures.

Yu Y, Hasegawa D, Chambers JK, Kojima K, Asada R, Johnson GS, Uchida K.
Frontiers in Veterinary Science, 2020 Nov 10;7:578936.

2020.11.10

The Number of Glutamines in the N-Terminal of the Canine Androgen Receptor Affects Signaling Intensities.

Ochiai K, Sutijarit S, Uemura M, Morimatsu M, Michishita M, Onozawa E, Maeda M, Sasaki T, Watanabe M, Tanaka Y, Omi T.
Veterinary and Comparative Oncology, 2020 Nov 10. Online ahead of print.

2021.03.17

牛トロウイルスN蛋白質の核輸送がウイルス増殖に必須であることを明らかにしました

氏家　誠（獣医学科、生命科学総合研究センター）他
Characterization of Localization and Export Signals of Bovine Torovirus Nucleocapsid Protein Responsible for Extensive Nuclear and Nucleolar Accumulation and Their Importance for Virus Growth.
Journal of Virology, 2021 Jan 13;95(3):e02111-20.

2021.02.10

イヌの軟骨肉腫から同定されたイソクエン酸脱水素酵素1の新規変異

落合　和彦(獣医学科、生命科学総合研究センター）他
Novel canine isocitrate dehydrogenase 1 mutation Y208C attenuates dimerization ability
Oncology Letters, 2020 20(6): 351

2020.12.15

がん幹細胞研究は犬の乳腺腫瘍の腫瘍発症機構の解明に必要不可欠である！

道下　正貴（獣医学科、生命科学総合研究センター）
Understanding of tumourigenesis in canine mammary tumours based on cancer stem cell research
The Veterinary Journal, 2020 265: 105560